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PeliCRM197® carrier protein made in Ligand’s Pelican Expression Technology® platform is the first and only commercially available cGMP CRM197 used in a marketed conjugate vaccine.

 A non-toxic mutant of diphtheria toxin, the PeliCRM197® carrier protein functions as a conjugation substrate for polysaccharides and haptens to enhance the immunogenicity of antigens in conjugate vaccines.  A 2018 publication comparing the quality attributes of the PeliCRM197® carrier protein demonstrated it to be the highest purity CRM197 available (Hickey JM et al., Jour. Pharm. Sci., 2018 (1806-19)).

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Scalability

We ensure scientists & manufacturing professionals have access to a continuous supply of research & cGMP grade PeliCRM197®, from milligrams to kilograms, throughout development and commercialization.

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Compliance

PeliCRM197® is supported by a Drug Master File (DMF) filed with the US FDA Center for Biologics Evaluation and Research (CBER). Access to the DMF simplifies regulatory filings, expediting time to vaccine approval.

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For research use, order PeliCRM197® online in a size that suits your needs. Visit our order page to read more about the product – including source, species, and formulation – and order today.

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